为了预防高原矿工作业时间长和工作任务繁重等因素引起的疲劳失误事故，针对高原缺氧、低温等环境特性，首先分析了人体作业疲劳积累特点，并通过构建高原矿山人体疲劳—作业失误机理图，概括了高原地区人体疲劳积累与作业失误的发生机制。其次，比较了不同海拔下人体生理机能和最大做工量的变化，划分出高原矿工疲劳积累的4个阶段（疲劳积累初期、疲劳积累稳定期、疲劳积累末期、疲劳恢复不可逆期（疲劳性损伤），基于对高原矿山作业者疲劳与行为错误之间关系的问卷调查分析，绘制出高原矿工各作业疲劳阶段失误率变化特征曲线。最后，运用人因分析和分类系统（HFACS），提出了高原矿山作业疲劳—人因失误框架（F-HFACS），全面分析了高原矿工疲劳的因素及其对人因失误发生的影响。研究表明：疲劳稳定期通常作业效率较高、失误率低且基本稳定；疲劳末期疲劳积累进一步加深，作业失误率激增，为防止疲劳性损伤，必须停止作业。该研究为高原矿山制定合理的轮班方案，降低作业失误率提供了科学依据。

Human fatigue is one of the main factors leading to safety accidents，especially for plateau operations with “low air pressure，low oxygen partial pressure，low temperature” and other characteristics，it is more likely to cause operator fatigue，not only greatly reduces workers’work efficiency，but also easy induce human accidents，which pose a threat to the life and safety of the operator.This article aims to prevent fatigue errors caused by factors such as long working hours and heavy tasks in plateau mines，and to ensure the safe production and occupational health of workers in plateau mines under low oxygen environment.Firstly，the characteristics of human fatigue accumulation were analyzed.The human fatigue-operation error mechanism map of plateau mines was built，and the mechanism of human operating errors caused by fatigue accumulation in plateau areas was summarized.Secondly，the changes in human physiological functions and maximum work volume at different altitudes were compared.The four stages of fatigue accumulation in high-altitude operation （initial stage of fatigue accumulation，stable stage of fatigue accumulation，later stage of fatigue accumulation，irreversible stage of fatigue recovery（fatigue damage）） are divided.Based on a questionnaire survey on the relationship between fatigue and behavioral errors of plateau mine operators，the characteristic curves of the error rate at different fatigue accumulation stages in the plateau mining was drawn，which initially revealed the change trend of error rate in the initial stage，stalble stage，later stage and irreversible stage （fatigue damage） of plateau workers’fatigue accumulation.Finally，using human factors analysis and classification system （HFACS），the paper proposed the Fatigue-Human Errors Framework （F-HFACS） of plateau mines comprehensively analyzes the factors of plateau miners’ fatigue and their impact on the occurrence of human errors.This study showes that there are higher operating efficiency，lower work error rate and better working stability at the stable stage than those at other stages；The fatigue accumulation further deepened at the later stage，and the working error rate is sharply increased，and to prevent fatigue damage，the operation must be stopped.The study provides a scientific basis for the safety management personnel of plateau mines to formulate a reasonable shift plan and reduce the operational error rate.